Product Information: Carnosine

The latest anti-aging supplement

This description concerns oral carnosine (as L-Carnosine) and carnosine eye-drops (as N-acetylcarnosine).

Carnosine (not to be confused with Carnitine) is a natural amino-acid that has been known about for decades. But it is only through recent Australian and British clinical and laboratory studies that the benefits of carnosine have become better known.

Carnosine has a number of interesting actions, it is a potent anti-oxidant, it helps to chelate ionic metals (i.e. flush toxins from the body), it has immune boosting properties (aid's wound healing) and is also known to reduce and prevent cell damage caused by beta amyloid (the substance found in the brain of Alzheimer disease patients). Carnosine helps protect neural tissues by blocking and inactivating beta amyloid and therefore it could help protect tissues against dementia. Recent evidence even suggests that carnosine has a important role in the sense of smell.

From the anti-aging standpoint, there are some very interesting carnosine actions, they are:

• Carnosine's ability to help prevent glycosylation- the cross linking of proteins (and DNA molecules) caused by sugar aldehydes reacting with the aminoacids on the protein molecule and creating Advance Glycosylation End-products (AGE's). If you want to see protein cross linking in action cut an apple in half and watch it turn yellow! Such anti-glycosylation may be beneficial for diabetes, cataracts, neuropathy, kidney failure and skin conditions, as well as "general" anti-aging properties, especially improving skin condition.
• In 1999, Australian researchers confirmed that carnosine increases the longevity of human fibroblast cells in the laboratory. Carnosine extended the Hayflick limit (the maximum number of times a cell can divide), from a "normal" 50 by up to an additional 10 times! Although not enough time has passed to test these results, carnosine may be a supplement of choice for longevity. It has been shown that animals with higher levels of carnosine appear to live longer than their controls.
• The Russians use Carnosine (in an eye-drop form) to help eradicate senile cataract problems with great success, (their clinical trials indicate an eye-condition improvement of 41.5% to 100% for patients within a 6-month period with sustainable results 24-months later). This type of carnosine eye-drop may have very important anti-aging eye functions because it is breaking protein cross-links, NOT just inhibiting them. Note however, that the Russians have been using a "special" kind of carnosine known as N-alpha acetylcarnosine or NAC for this purpose. It is not "just" L-carnosine as an eye-drop. Dr. Mark Babizhayev, one of the scientists behind the Russian clinical trials stated; "L-carnosine means nothing for the treatment of human cataracts because it readily becomes hydrolyzed with the serum carnosinase in the aqueous humor.Besides, L-carnosine appears even dangerous for the treatment of ocular disorders, as it gradually releases histamine via the activity of histidine decarboxylase."

EYE-DROPS N-ACETYLCARNOSINE
A breakthrough in the battle against senile cataract

We present a remarkable new anti-aging breakthrough is a special form of carnosine, called N-acetylcarnosine, which has been successful in the reversal of senile cataract!

The NAC eye-drops to be used for the treatment of cataract require 2-drops into each eye, twice daily for a period of 6-12 months (although due to the nature of senile cataract a permanent continuance may be advisable). Dr. Babizhayev in his interview states that the best results are achieved in the 3 to 5 month period. For preventative use, 1-drop into each eye daily with frequent breaks may be more practical. To date no serious side effects have been noted in any of the trials, (this is probably because the Russians have developed a unique form of N-acetylcarnosine eye-drops, whereby they have removed the majority of metals and salts, thereby reducing the possibility of side-effects).

For preventative use, 1-drop into each eye daily with frequent breaks may be more practical. It is also recommended that occasional use of N-acetylcarnosine eye-drops continue even after the reduction/ reversal of the cataract. This is because senile cataract is an on-going aging problem caused by low anti-oxidant protection/ high free radical production and the process of glycosylation etc.

To date, no serious side effects or contraindications have been noted in any of the clinical trials. This is probably because the Russians have developed a unique formula and form of N-acetylcarnosine eye-drops, whereby they have removed the majority of metals, thereby reducing the possibility of side-effects. This special version of N-acetylcarnosine has been patented by Innovative Vision Products.

N-acetylcarnosine eye-drops are available under the trade name of Can-C® and we are proud to announce that we offer the same formula, proven in the clinical trials, as well as formulated and patented by Innovative Vision Products.

ORAL L-CARNOSINE
Extending the Hayflick limit

Carnosine oral supplementation is a relatively new area, normal current anti-aging dosages are 50mg-150mg of L-carnosine per day, (maximum 200mg day) with occasional breaks. Such dosages have failed to produce any report of serious side effects or contraindications to date.

We don't recommend larger oral dosages than 200mg per day because it may be that some of the advantages of oral carnosine supplementation comes from its breakdown. Furthermore, we know of cases of disturbing muscle twitching with 1g plus dosages. You can click here to see the results of a clinical trial that show 100mg-200mg of carnosine daily are effective, and that in-fact dosages of more than 500mg daily may be less effective.

The synergetic and protective use of Lucidril (centrophenoxine) may be beneficial with long-term oral Carnosine use.

Directions:
1 or 2 drops in each eye 1-4 times a day or as directed by a physician. Please read the enclosed product insert carefully. For the proper installation of drops, lean head back and look up. Do not blink or reopen the eye for 60-seconds. Repeat this procedure, if a second drop is used. Closing the eye allows each drop to be absorbed into the eye tissue. Blinking, even one or two times, will pump most of the solution out of the eye. If you have neck problems, lie down or use a tilt-back chair.

Indications:
For temporary relief of discomfort due to minor irritations to the eye or exposure to wind or sun. For use as a lubricant and protectant against irritation or to relieve dryness of the eye.

Eye Drop Information:
Active ingredients: Glycerine (lubricant) 1% , Carboxymethylcellulose sodium (lubricant) 0.3%. Inactive ingredients: Sterile Water (ophthalmic grade solution pH 6.3 to 6.5). Antioxidants: N-Acetyl-Carnosine (NAC)* 1%. Buffers: Borate, Potassium Bicarbonate. Preservative: Purified Benzyl Alcohol. Please read enclosed product insert for instructions on opening tubes. (*patented by Innovative Vision Products).

Warnings:
To avoid contamination, do not touch the tip of container to any surface. Replace the cap immediately after using. Open only one container of solution at a time. Do not allow other people to use your container. Once open, discard container and any contents after 30-days. Do not heat beyond room temperature, keep the extra tubes in the box away from light, especially sunlight. Do not freeze. Do not use if seal is broken or if solution changes color or becomes cloudy. Not recommended for children under the age of 12 years. If the eye tissue becomes more inflamed, red, irritated or uncomfortable after using this product, immediately discontinue the use of product and consult an eye-physician if necessary. Keep this and all drugs out of the reach of children.

TO OPEN CONTAINER:
Push firmly down on the cap until the punch on the inside of cap punctures the top of the container. Once punctured, the lid will go down far enough to create a seal on the dispensing nozzle.

TO REMOVE THE CAP:
Use a slight twisting action while pulling the cap away from the container.

TO DISPENSE A DROP:
Remove the cap and squeeze the container gently until a drop is dispensed.

TO RESEAL THE CONTAINER:
Replace the cap over the dispensing nozzle and push firmly down until the cap makes a seal with the base of the nozzle.

STORAGE:
This product can be stored at normal room temperature, however to obtain maximum shelf life of the ingredients, the product should be stored in the refrigerator, but do not freeze. Do not use past expiry date.

STATEMENT:
This product is manufactured in accordance with the requirements as set forth by the Food and Drug Administration monograph for ophthalmic products. The statements contain herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

L-Carnosine is the latest discovery in the amino-acid field. A natural anti-oxidant and potentanti-glycosylation agent its role in helping aging, cataract, diabetes, kidney problems and neuropathy is just coming to light.

Ingredients: Contains L-Carnosine (50mg) and rice flour per gelatine capsule.

Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease.

Always: Follow your physician's advice. Keep away from children, pregnant or lactating women.

Application: 1 to 4 capsules per day.

Note: Store in a dark cool place. Do not use past expiry date.