Product Information: Nicergoline (Sermion®)
Nicergoline is an ergoloid mesylate derivative (akin to Hydergine®), that is currently being used in the battle to treat senile dementia. Interestingly it has been found to improve mental agility more through enhancing perception and vigilance. In this way it is different to the effects of Hydergine (which improves oxygen stability and increases mental ability - i.e. it extends the period of useful mental workload, and has been designated as an IQ booster with its brain dendrite stimulation). Nicergoline on the other hand appears to enhance clarity, perception and vigilance.
Nicergoline has alpha-adrenolytic action which activates the brain's metabolism and improves arterial flow, lowers vascular resistance and improves the use of glucose and oxygen. Furthermore, it is known that Nicergoline inhibits platelet aggregation. Interestingly, animal experiments have shown that Nicergoline increases nerve growth factor in the aged brain.
Accordingly, Nicergoline is being used to help treat migraines of vascular origin, as well as blood problems such as transient ischemia (occasional blood supply difficulties), platelet hyper-aggregability (sticky blood platelets), improving limb blood-irrigation and lung blood-circulation. It is also being used for macular degeneration.
Persons suffering from acute bleeding, myocardial infarction (heart conditions), hypertension, bradycardia or using alpha or beta receptor agonists should consult with their physician before use. Nicergoline is known to enhance the cardiac depressive effects of propranolol (Inderal®) - caution is advised.
Like nearly all nootropics, nicergoline has been shown in clinical trials to be safe when used with respect. Side effects include insomnia, hot feeling, mild gastric upsets, hypotension and dizziness and is normally an indication of over-dosage or over-stimulation through synergistic combinations. If utilizing nicergoline with other nootropics, always reduce the individual doses and only increase to larger doses over several days.
At high dosages, seek your physician's advice if combining with potent vasodilators such as Bromocriptine, Ginko Biloba, Hydergine®, Picamilone, Vinpocetine or Xanthinol Nicotinate.
Furthermore, as with all nootropic products, occasional breaks are recommended (i.e. 1-week per month or 2-days per week).
Dosages for the treatment of senile dementia have been as high as 30mg to 60mg daily, however treatment and protection from ARMD and the above listed blood disorders would normally indicate 5mg once, twice or three times daily.
Studies carried out in vitro and in vivo, both experimental and on human beings, have shown that Sermion (nicergoline) inhibits platelet aggregation. Sermion (nicergoline) has proved to be effective in hospital use, regulating and improving brain disorders caused by metabolic-vascular insufficiency and alterations derived from insufficient arterial irrigation in the limbs. When the therapeutic dosage is administered, Sermion (nicergoline) does not affect arterial tension. In the case of patients suffering from hypertension, it may induce a gradual lowering of tension.
This pharmaceutical product does not induce vomiting.
Migraines of vascular origin
Coadjutant therapy in clinical situations accompanied by platelet hyper-aggregability, arterial tension
Corio-retinal vascular disorders: retinal thromboses, diabetic retinopathy, macular degeneration and retinal angiosclerosis
Oto-vestibular problems of a vascular nature: dizziness, auditory hallucinations, hypoacusis.
Directions for using Drops:
Intoxication and Treatment:
Keep this and all other medicines safely out of the reach of children.
© 2001 - 2008 Biogenesis Laboratories