Product Information: Oxitriptan - Triptoh - 5HTP

Product Information
Otherwise known as 5-hydroxy-tryptophan or Oxitriptan. 5HTP is the actual precursor of serotonin, (the brain neurotransmitter linked with pleasure and fulfilment).

5-HTP and Serotonin. 5HTP is often used in the place of SSRI drugs and L-Tryptophan in the treatment of depression and epilepsy, as a result 5HTP has many similar uses such as the assistance of sleep and alleviation of age related mental depression, as well as alcohol withdrawal.

Very high doses of 600mg per day have been employed, but these must be avoided unless also taking Carbidopa to avoid serotonin crossing into the bloodstream.

Safe and normal doses are 50mg to 100mg (200mg-maximum) daily. Avoid use with other serotonin enhancing agents, such as L-Tryptophan or other serotonin enhancing drugs such as SSRI drugs like Prozac( etc without your physician's guidance.

The 5HTP brand we supply is called Tript-Oh and it is Italian pharmaceutical quality. Furthermore, it is contained in enteric coated capsules which helps to avoid stomach upset.

Manufacturers Insert
Capsules

Chemical: 5HTP is 5-Hydroxy-Tryptophan, also known as Oxitriptan is the direct physiological precursor of Serotonin, an essential chemical agent of the brain. Among the different pathogenic factors of neurological and psychic illnesses (particularly depression), the role played by biochemical cerebral alterations has been carried out on metabolic alterations of biogenous amines, resulting in the amine hypothesis of the pathogenesis of these disorders. In the genesis of neuropsychiatric disorders, sufficient evidence has been found to stress the importance of an alteration of cerebral activity caused by the imbalance of the synthesis, storing up, freeing or inactivation of amines, and of serotonin in particular. This is in fact reduced in the brain tissue of depressed patients just as the rate of their metabolite; 5-hydroxy-indole acetic acid is reduced in the liquid of these patients. A positive correlation has also been seen between the degree of depression and the combination of this metabolite, in addition to an increased period of clinical recovery following electrotherapy or treatment with tricyclic antidepressants and MAO inhibitor. In certain neurological syndromes there is also a shortage of serotonin. Because exogenous serotonin is unusable, it must be synthesized in the places of action beginning with the amino acid precursor, Tryptophan. However only 1% of exogenous Tryptophan is transformed into serotonin. Oxitriptan on the other hand, easily crosses the haematoencephalic barrier, avoiding the obligatory passage of Tryptophan- hydroxylation, and is completely transformed into serotonin by the presence of a specific enzyme in the brain tissue, 5- hydroxytryptophan decarboxylase. Toxicological studies on Oxitriptan have shown that the product is absolutely harmless, and these hypotheses and pharmacological results have been confirmed by clinical experience in different sectors of neuropsychiatric pathology.

Excipients: Capsules, starch, mannitol, magnesium stearate. The capsule is composed of gelatine, indigotin, (50-mg and 200-mg caps), titanium dioxide, yellow iron oxide, (100-mg and 200-mg caps), erythrosin (100-mg and 200-mg caps). Sachets, Sodium hydroxy-ethyliden methyl pirandione, apricot aroma, polyethylene glycol, sucrose for coating.

Information for the user: In psychiatry, Oxitriptan is a useful adjutant in Psychogenic depression and Endogenous depression and Involutional depression. This pharmaceutical product may be used together with other specific treatments, with MAO inhibitors and also, though the dosage may have to be modified, with tricyclic and quadricyclic antidepressants.

In neurology, Oxitriptan is a useful adjutant in Epilepsy (together with anticonvulsant) and Parkinson’s disease (together with L-Dopa) and Myclonus and Choleric movements and Down’s Syndrome and Phenylketonuria.

Other uses include Migraine and Vasomotor Cephalalgia and Sleep Disorders (Insomnia and hypersomnia) and Centrally originated painful syndromes.

Directions for use: Initial dosage 200mg per day to be subsequently increased to the maintenance dosage- - States of depression 300mg to 600mg per day - Neurological syndromes 600mg to 1000mg per day - Epilepsy 150mg to 300mg per day (half dose for children) - Parkinson’s disease 100mg to 600mg per day. For Down’s syndrome, the initial dosage is 1mg per Kg body weight per day, and will vary according to therapeutic results. The daily dosage will be divided into three separate doses. The contents of the packet are to be dissolved in half a glass of water.

Contraindications: Serious renal insufficiency. Hypersensitivy to the product on the part of the patient.

Precautions: On the basis of these contraindications, it is advisable when in doubt to undergo a through renal and cardiac examination before beginning this treatment. Alpha-methyldopa and methysergide block the peripheral decarbixylization of Oxitriptan; thus patients being treated with these substances should take Oxitriptan with caution.

Side Effects: In strong doses, this pharmaceutical product may occasionally cause nausea and minor gastric discomfort. Should this occur, reducing the normal dosage for a few days and later resuming it is usually sufficient. If necessary, antacid products or those that modify the behavior of the digestive tract may be taken.

Warning: This product must be protected from the light. It is available only through prescription and should be taken only under medical supervision. Keep out of the reach of children.