Product Information: Reminyl (Galantamine)
Reminyl Tablets -Galantamine
Reminyl Tablets-14 -Galantamine
A new treatment for Alzheimer's disease
or Reminyl® is the drug extract version of a snow-drop family, the
specific chemical being Galantamine. Specifically, Reminyl® has been
shown to be a reversible inhibitor of acetylcholinesterase, which is an
enzyme that acts upon acetylcholine to break it down.
As acetylcholine is the primary messenger neurotransmitter that is affected
in Alzheimer's Disease, Reminyl® is now being used as a front line
treatment for the same.
However, it is also worth noting that Reminyl® also acts upon nicotine
receptors in the brain, stimulating them. This action has been noted as
being of importance to the efficacious role that it appears to take as
an anti-depressant, furthermore anecdotal evidence points to Reminyl®
also having a potential role in weight loss, due to its appetite suppressant
Reminyl 4 mg, 8mg and 12 mg Tablets (galantamine
hydrobromide). This leaflet contains important information. Please read
it carefully before taking your medicine. If you are a carer and will
be giving Reminyl to the person you look after, it is also important that
you read this leaflet on their behalf. If you have any questions or concerns
after reading the leaflet, speak to your doctor or pharmacist.
What is Reminyl (Galantamine)?
The name of this medicine is Reminyl, it contains the active
ingredient galantamine hydrobromide. Reminyl comes in 3 different strengths
of tablets, as indicated below:
- the off-white tablets contain 4 mg galantamine
and are marked G4;
- the pink tablets contain 8 mg galantamine and
are marked G8;
- the orange-brown tablets contain 12 mg galantamine
and are marked G12;
The tablets also contain the inactive ingredients
colloidal anhydrous silica, crospovidone, hypromellose, lactose monohydrate,
magnesium stearate, microcrystalline cellulose, propylene glycol, talc
and titanium dioxide (E111). The tablets contain the following colouring
agents: 4mg tablets: yellow ferric oxide (E172); 8 mg tablets: red ferric
oxide (E172); 12 mg tablets: red ferric oxide (E172) and orange yellow
S aluminium lake (E110). Warning: The colouring E110 in the 12mg tablets
can cause an allergic reaction, like asthma, in some people. An allergic
reaction to E110 is more likely in people who are allergic to aspirin
(acetylsalicylic acid). Speak to your doctor for advice before taking
any tablets. The 4 mg tablets come in packs of 14 tablets, the 8 mg tablets
in packs of 14 or 56 and the 12 mg tablets in packs of 56 or 168. The
marketing authorization for Reminyl is held by Shire Pharmaceuticals Limited,
East Anton, Andover, Hampshire SP10 5RG, UK. The tablets are manufactured
by Janssen-Cilag SpA, Via C Janssen, Borgo San Michelle, 04010 Latina,
What is Reminyl for?
Reminyl is used to treat the symptoms of mild to moderately
severe dementia of the ~ Alzheimer type, a disease that alters brain function.
The symptoms include progressive memory loss, increasing confusion and
behavioral changes. As a result, sufferers find it becomes more and more
difficult to carry out their normal daily activities. Symptoms of dementia
of the A1zheimer type are believed to be related to a lack of acetylcholine,
a substance responsible for sending messages between brain cells. Reminyl
works by increasing the amount of acetylcholine in the brain and so improves
the symptoms of the disease.
When Reminyl should not ne used?
Reminyl should not be taken:
- By people who have had an allergic reaction
to galantamine (Reminyl) or to any of the other ingredients. Check the
ingredients by reading the section above called 'What is Reminyl'. An
allergic reaction may be recognised as a rash, itching, swollen face
or lips, or shortness of breath
- By people who have either severe liver or severe
kidney disease. By people who have significant, combined liver and kidney
problems. Speak to your doctor if you suffer from these problems or
have suffered from them in the past.
Before taking Reminyl:
Medicines are not always suitable for everyone. Do you have any of the
following conditions: Have you suffered from these in the past? Liver
or kidney problems; Heart disorders; Stomach ulcer or duodenal ulcer;
Acute abdominal pain; Epilepsy; Respiratory diseases that affect breathing
(like asthma); A recent operation on the gut or bladder or difficulties
in passing urine; Galactose intolerance, lactase deficiency or glucose-galactose
malabsorption. As Reminyl contains lactose it may not be suitable for
If the answer to any of these questions is 'Yes', speak to your doctor
for advice before any Reminyl is taken. Your doctor will decide whether
this medicine is suitable for you. Your doctor may adjust the amount of
medicine that you take.
If you are pregnant, trying to become pregnant or breast-feeding, do not
take any Reminyl before speaking to your doctor for advice. If you need
to have a general anesthetic for an operation, tell the doctor that Reminyl
is being taken.
Reminyl is not recommended for children. Reminyl is not recommended for
driving or operating machinery (Reminyl, as well as the disease itself,
can affect the ability to drive or operate machinery. Please discuss this
with your doctor).
Always tell the doctor; nurse or pharmacist if any other medicines
are being taken because taking some medicines together can be harmful.
Reminyl should not be taken with other medicines that act the same way.
If medicines for diarrhea, Parkinson's disease or asthma are taken, check
with your doctor to see if these affect Reminyl. Tell your doctor if drugs
for certain heart disorders or high blood pressure (e.g. digoxin or the
so-called beta-blockers) are being taken.
Your doctor may prescribe a smaller dose of Reminyl if certain drugs are
being taken at the same time (for example certain antidepressants (such
as paroxetine, fluoxetine or fluvoxamine), quinidine (used for heart rhythm
problems), ketoconazole (an antifungal or ritonavir (a treatment for HIV).
If you are not sure, speak to your doctor or pharmacist
How to take Reminyl:
Reminyl should be taken by mouth. It should be taken twice a
day, preferably with morning and evening meals.
Reminyl is usually started at a low dose. Your doctor may then slowly
increase the amount of Reminyl that you take to find the most suitable
dose for you.
Treatment with Reminyl is usually started at a dose of 4 mg taken twice
daily. This dose will be taken for at least four weeks. Your doctor will
then increase the dose to 8mg taken twice daily. This dose will be taken
for at least 4 weeks. If your doctor decides to increase your dose again,
you should take 12 mg twice daily.
What if a dose of Reminyl is forgotten?
If a dose is missed, the next dose should be taken as usual. Then continue
as before. If more than one dose has been missed, contact your doctor
for advice. Do not take 2 doses at the same time to make up for a missed
If too much Reminyl has been taken, contact a doctor or hospital
straightaway. Take any remaining tablets and the packaging with you.
After taking this medicine:
If undesired effects such as nausea and vomiting occur, they
are mainly experienced early on in the treatment or when the dose is increased.
They tend to disappear gradually as the body gets used to the treatment
and generally will not last for more than a few days. If you are experiencing
these effects your doctor may recommend that you drink more liquids and,
if necessary, they may prescribe medicine to stop you being sick.
Other possible side effects include: abdominal pain, diarrhea, indigestion,
decreased appetite and weight loss. Also, headache, dizziness, tiredness,
sleepiness or sleeplessness and confusion might be experienced as well
as a runny or blocked nose, a urinary tract infection and falling, sometimes
resulting in injury.
In very rare cases trembling has occurred. A slow heartbeat or fainting
has also been reported. Should such symptoms be experienced, contact a
doctor as medical assistance might be necessary.
Do not be alarmed by this list of possible side effects. You may not have
any of them. Tell your doctor or pharmacist if you are worried or think
that Reminyl is causing you any problem.
How to store Reminyl:
As with all medicines, Reminyl should be kept in a safe place where children
cannot see or reach it. There are no special storage instructions for
Reminyl tablets. Medicines can be kept for a limited period only. Therefore,
do not use Reminyl after the date printed on the packaging. Always return
any leftover medicines to your pharmacist.