Product Information: Retin-A Cream and
Gel (Retirides® & Kefrane®)
Retin-A Cream - Tretinoin
Retin-A Cream - Retirides
Cream at 0.05% strength
Retin-A Cream - Retirides
0.100% represents the strongest
strength for acne
Still the best anti-wrinkle skin product
product contains tretinoin, (sometimes called retinolic acid), derived
from vitamin A.
Retin-A® is a treatment for acne and black spots, yet displays a
remarkable talent to remove wrinkles and improve skin appearance and condition.
Retin-A® can reduce severe wrinkles within only 6-weeks and remove
fine lines, and it remains at the cutting-edge of beatifying skin treatments.
Indeed, many of the expensive skin-creams found at the local store boast
of their extremely minute quantities of retinolic acid! This is because
Retin-A® improves blood supply to the skin, which in-turn increases
the turnover of dead skin cells. Accordingly, new more subtle and younger
looking skin appears at the surface.
remains at the forefront of many celebrities anti-aging skin programs,
not only because of its anti-wrinkle and skin enhancing affects, but also
because it helps speed cosmetic surgery repair.
Retin-A® should be applied sparingly to the skin's surface avoiding
the eyes, at first 5 times a week, and thereafter about 3 times a week.
Without your physician's advice, do not apply to skin suffering from psoriasis,
eczema, or if you are suffering from a form of skin cancer.
We offer dermatological strengths of the standard 0.025%, the most widely
used 0.05% cream (which is designed for wrinkles) and the very high strength
0.1%, (which is designed for acne). If you have never used this product
before, we strongly recommend that you start at the lowest dosage and
if necessary, work your way up slowly.
Rub the cream or gel sparingly into the skin until the product has been
completely absorbed, (avoid the eyes; rinse with cold water immediately
if accidentally placed there). It is recommended that a moisturizer be
used, (see NeySkin®) and a high factor sunscreen. This is because
Retin-A® increases skin sensitivity.
Retin-A® may cause skin reddening at first, this is quite normal
as the skin's blood supply is improved and younger looking skin begins
to appear presenting that "youthful glowing affect."
Our current brands of Retin-A® cream are called Retirides® and
Tretinoin BP 0.025%, 0.05% or 0.1% cream and 1g excipients c.s.p.
Decyl oleate, isopropyl myristrate, glyceryl monostearate, acetyl lanolin
alcohol, ceteareth-30, cetyl alcohol, proline, monostearate of polyethylene
glycol 400, urea, collagen, methylparaben, propylparaben, lactic acid,
sodium citrate, sodium hydroxide, vitamin E, aroma, and purified water.
Tretinoin or vitamin A acid, the single active ingredient used in Retirides,
is a cellular stimulant which is effective in the treatment of common
Information for users:
Retirides 0.05% is recommended for the external treatment of common acne,
especially in the case of blackheads, pimples and papules.
Apply a sufficient amount of cream so as to cover the affected area with
a thin layer. Massage gently. Retirides is available in 3 different strengths
(0.025%, 0.5% and 0.1%). Your doctor will prescribe the appropriate strength
depending on your skin type and degree of acne, and will also recommend
the number of daily applications necessary. It is advisable to start the
treatment with a low concentration of the cream and a single daily application.
Following this and according to the patient’s individual needs,
the strength and/ or number of daily applications may be increased.
If any ingredient should cause hypersensitivity, discontinue use.
Due to the possibility of irritation, it is advisable to begin treatment
on a small area of skin. Exposure to the sun or to ultraviolet rays causes
additional irritation. During treatment with Retirides, such exposure
should thus be avoided as much as possible or a dun filter should be used.
In the event of exceptional exposure (such as a day at the seaside), refrain
if possible from applying the cream the day before, the day of exposure
to the sun and the day after exposure. Keep Retirides away from the eyes,
mouth and nose. Should contact occur, rinse the affected area carefully
with abundant water.
If the patient has been previously treated with keratolytic preparations
or exfoliants, he should wait until the skin rash clears up before beginning
even low strength Retirides treatment. Studies of the effect of this product
on pregnant women are incomplete. For this reason, it should only be applied
when absolutely necessary and always under a doctor’s supervision.
It is thought that this product may possibly be excreted into mother’s
milk. Retirides should thus be used with caution by nursing mothers.
This product should be used with caution due to the possible interaction
of tretinoin with concomitant external medication, abrasive soaps, drying
cosmetics and products with a high alcohol content. Care should also be
taken regarding the application of preparations containing sulphur, resorcinol
or salicylic acid.
The effectiveness of tretinoin based products is almost always accompanied
by skin irritation. In the treatment of acne, this phenomenon is directly
related to the effectiveness of the product and disappears once applications
are more spaced out. During the first weeks of treatment there may be
an apparent worsening of the problem. Such a reaction is perfectly normal
because small cysts deep within the skin are being eliminated at an accelerated
Acne may worsen during the first two or three weeks of treatment. Should
this occur, do not interrupt treatment unless skin rash or other symptoms
become severe. Avoid washing the face frequently. Doing so with a neutral
soap two or three times per day is sufficient. Dry face without rubbing.
Wait a full half-hour before applying the cream. Avoid the simultaneous
application of other external acne products and the use of perfumes, colognes,
and tonics, lotions which are scented or which contain alcohol. These
products may irritate the skin.
Intoxication and its treatment:
Overdose of this product is unlikely if the patient realizes that an increased
application does not bring better or quicker result. Likely reactions
would be a marked inflammation, flaking and discomfort. In addition, the
DL 50* of tretinoin is very high and skin absorption very low (approximately
5% of the dosage administered).