Over many years SAMe has been given both orally
and intravenously to tens of thousands of patients with great clinical
success and extremely minimal side effects."
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Product Information: SAMe
A superb methylation agent for mental and physical improvement
There is also a correlation between SAMe and Melatonin, when Melatonin levels are low SAMe levels are high and vice-versa. SAMe has been described as the daytime alertness hormone, in the same way that Melatonin has been described as the night time sleep hormone.
SAMe is the 3rd most concentrated chemical in the liver, so it has been widely used to correct liver disorders such as cirrhosis and even hepatitis. Being natural, SAMe doesn't suffer have any of the serious side effects that are associated with other liver drug treatments.
Recent clinical evidence points to SAMe as a potent anti-depressant, (however its use should be avoided with patients who suffer from manic depression), because of its energy enhancing affects SAMe has become one of the most sought after anti-depressants of recent times.
SAMe has even been found to be efficacious for osteoarthritis.
Antidepressant uses may require 500mg to 2000mg daily, (only use other antidepressant drugs with your doctor's guidance). Osteoarthritis doses are around 1000mg daily, liver disorders between 500mg and 1500mg daily, but general anti-aging purposes appear to be about 300mg to 500mg daily.
Keep the tablets cool and out of sunlight and do not remove the tablets from the blister pack until you are ready to take them. SAMe tablets are enteric coated so they should not be crushed or broken.
Avoid use of SAMe's that are not enteric coated and not protected from light!
Ingredients: One 500-mg phial of lyophilized substance contains ademethionine (Sulphur-Adenosil-L-Methionine) 1.4-butandisulphonate 949 mg equal to ion 500 mg. One ampoule of solvent liquid contains water for preparing injections, L-lysin, sodium hydroxide.
One 500-mg gastro-resistant tablet contains: ademethionine (Sulphur-Adenosil-L-Methionine), 1,4-butandisulphonate 949 mg equal to ion 500 mg. Excipients: microcrystalline cellulose, magnesium stearate, polyethylene glycol 6000, polymethacrylate, polysorbates, colloidal silica, emulsified silicone, and sodium-starch glycolate talc.
Pharmaceutical classification: For the treatment of cholestasis. DONAMET is recommended for the treatment of intrahepatic cholestasis in pre-cirrhotic and cirrhotic conditions. Treatment of intrahepatic cholestasis during pregnancy.
Contraindications: Individual hypersensitivity to the product.
Caution: The lyophilized substance must not be mixed with the solvent liquid until immediately before use. Intravenous injections should be administered very slowly. DONAMET tablets are gastro-resistant and thus protect the duodenum from the Ademethionine. The tablets should not be removed from the blister until immediately prior to taking them. Tablets are to be swallowed whole, not chewed. For better absorption of the main active ingredient and hence a more complete therapeutic effect, it is recommended that DONAMET not be taken with meals but rather between them. In the case of pre-cirrhotic or cirrhotic patients with hyper ammonia, oral treatment must be carried out under a doctor's supervision and bearing in mind the ammonia values.
Interactions: Marked interactions have not been shown.
Please take note: DONAMET does not affect the patient's capacity to drive or operate machinery.
Directions for use: Intensive treatment: 5-12 mg/kg/day to be administered by intramuscular or intravenous injection for the first two weeks of treatment (equivalent to 300-800 mg/day). Follow-up treatment: 10-25 mg/kg/day to be taken by mouth (equivalent to 800-1600 mg/day).
Overdose: No cases of overdose have been reported.
Side effects: Side effects have not been seen either in long-term treatment or when taken in high doses. Rarely, and only in those who are particularly sensitive, has DONAMET caused disturbances in the patient's waking-sleeping rhythm. In such cases the use of a sleeping pill in the evenings may prove to be effective. Given the high pH acidity level of DONAMET to ensure its effectiveness, certain patients have reported cases of heartburn and epigastric heaviness. However such discomfort is minor and should not interfere with treatment.
If the patient notices any side effect not described in this leaflet he should consult his doctor.
Expiry date: Observe the expiry date on the packaging of this product. It refers to the unopened product when properly stored.
Attention: Do not use this medicine once its expiry date has passed. Store DONAMET at a maximum temperature of 25º C. If the lyophilized substance should take on a colour other than white, due either to a small breakage of the phial, or exposure to heat, we recommend that the patient return the entire package to the chemist to be changed. Similarly, if the tablets should take on a colour other than white due to the presence of small holes in the aluminum covering, return the entire package to the chemist to be changed.
Easy opening safety ampule: Instructions for opening - Position the ampoule as shown in figure 1. - Exert pressure with the thumb on the COLOURED DOT as shown in figure 2. If the lot number shown on the box includes the letter "B", the phials of lyophilized material have been manufactured by Boehringer Mannheim Italia Spa in the Monza (Milan) office. If the lot number shown on the box includes the letter "F", the Fidia Spa has manufactured the phials of lyophilized material in the Abano Terme (Padua) office.
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